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I Have Good News To Share!  
User currently offlineSmithAir747 From Canada, joined Jan 2004, 1628 posts, RR: 28
Posted (8 years 4 months 2 weeks 5 days 17 hours ago) and read 2000 times:

For those of you who have met me in person, or know me from here, I have been in London, UK, for 2 years now, studying at King's College London (Guy's Hospital campus, London Bridge). My goal has been to be a research doctor, specialising in the research of rare genetic craniofacial disorders (Treacher Collins syndrome, etc). This stems from my lifetime experience with Treacher Collins syndrome.

Earlier this year, I applied for a Wellcome Trust UK Summer Studentship Research Grant, to do a summer supervised research project with a professor in KCL/Guy's Hospital's Department of Craniofacial Development. The money would enable me to stay here in London this summer for 8 weeks and do the research project (and especially, get first-hand laboratory research experience, essential for my career prospects and CV). In March this year, my professor and I sent the application into Wellcome Trust with crossed fingers. My friends and family at home in the USA have been praying and waiting anxiously for me to get this grant.

Today, I found out that I have won this grant for my summer research project.
That means I get to stay here in London for 8 weeks this summer (early June-early August), while I work in this professor's laboratory with him.

So, I will remain here in London for most of this summer, and won't make it home to the USA until mid-August.

I'm very excited about this opportunity for this summer; it will be a valuable learning experience (and since I really want to get into this emerging research field, it will help my future career prospects and my CV). It will also help prepare me for my required 3rd-year project.

For my third year at KCL (next year), I have also been selected as one of the first few students to participate in a new third-year Craniofacial Sciences research-based curriculum; I already have my project lined up for this, too.

So, Kazzie and the others who have met me, thanks for your thoughts and wishes--they really helped!

SmithAir747


I will praise thee; for I am fearfully and wonderfully made... (Psalm 139:14)
20 replies: All unread, jump to last
 
User currently offlineKazzie From , joined Dec 1969, posts, RR:
Reply 1, posted (8 years 4 months 2 weeks 5 days 17 hours ago) and read 1991 times:

Fantastic News Frances  Smile

Its an amazing thing your doing, lets hope it leads to an even bright future for you  Smile


User currently offlineCastleIsland From , joined Dec 1969, posts, RR:
Reply 2, posted (8 years 4 months 2 weeks 5 days 16 hours ago) and read 1944 times:

Congratulations, Francis. No doubt well-deserved. It appears that your drive and determination to enter a very worthy and challenging field is starting to pay dividends.

User currently offlinePilotaydin From Turkey, joined Sep 2004, 2539 posts, RR: 51
Reply 3, posted (8 years 4 months 2 weeks 5 days 16 hours ago) and read 1944 times:

hey man, i am openly admitting i know nothing about your area of expertise.... but it sounds like you're doing something fabulous, so good luck!

and good job



The only time there is too much fuel onboard, is when you're on fire!
User currently offlineAerobalance From United States of America, joined exactly 14 years ago today! , 4682 posts, RR: 46
Reply 4, posted (8 years 4 months 2 weeks 5 days 16 hours ago) and read 1931 times:

Congrats!!!!
The message you were about to post is too short and probably not of any higher value to the topic at hand.



"Sing a song, play guitar, make it snappy..."
User currently offlineNighthawk From UK - Scotland, joined Sep 2001, 5157 posts, RR: 33
Reply 5, posted (8 years 4 months 2 weeks 5 days 16 hours ago) and read 1904 times:

Congrats smithAir!

I have to say im rather impressed with you, most people would probably hide away and have trouble dealing with their condition, but not you. Your out there living the life you want, and pushing yourself to be the best, and at the same time researching the condition to better understand it and hopefully make life easier for other suffers.

Congratulations again on gaining the funding!



That'll teach you
User currently offlineKazzie From , joined Dec 1969, posts, RR:
Reply 6, posted (8 years 4 months 2 weeks 5 days 16 hours ago) and read 1891 times:

Quoting Nighthawk (Reply 5):

I have to say im rather impressed with you, most people would probably hide away and have trouble dealing with their condition, but not you. Your out there living the life you want, and pushing yourself to be the best, and at the same time researching the condition to better understand it and hopefully make life easier for other suffers.

*tick and goldstar*


User currently offlineKROC From , joined Dec 1969, posts, RR:
Reply 7, posted (8 years 4 months 2 weeks 5 days 15 hours ago) and read 1859 times:

Congrats! Very good to hear!

User currently offlineMir From United States of America, joined Jan 2004, 21641 posts, RR: 55
Reply 8, posted (8 years 4 months 2 weeks 5 days 14 hours ago) and read 1820 times:

Great news, congratulations!

-Mir



7 billion, one nation, imagination...it's a beautiful day
User currently offlineScarletHarlot From Canada, joined Jul 2003, 4673 posts, RR: 56
Reply 9, posted (8 years 4 months 2 weeks 5 days 13 hours ago) and read 1800 times:

Francis! That's excellent. Congratulations!  Smile


But that was when I ruled the world
User currently offlineDL021 From United States of America, joined May 2004, 11447 posts, RR: 75
Reply 10, posted (8 years 4 months 2 weeks 5 days 13 hours ago) and read 1781 times:
Support Airliners.net - become a First Class Member!

Outstanding!!!

Proud of you! Now we'll be able to hang out in July at the airshow.

Keep at it, and we'll speak soon. Looking forward to meeting you in person.



Is my Pan Am ticket to the moon still good?
User currently offlineBMIFlyer From UK - England, joined Feb 2004, 8810 posts, RR: 58
Reply 11, posted (8 years 4 months 2 weeks 5 days 13 hours ago) and read 1769 times:

Nice one Big grin


Lee



Sometimes You Can't Make It On Your Own
User currently offlineFlyingbabydoc From , joined Dec 1969, posts, RR:
Reply 12, posted (8 years 4 months 2 weeks 4 days ago) and read 1668 times:

Quoting SmithAir747 (Thread starter):
My goal has been to be a research doctor, specialising in the research of rare genetic craniofacial disorders (Treacher Collins syndrome, etc). This stems from my lifetime experience with Treacher Collins syndrome.

Congratulations, Frances. I would be very interested in learning more about your research, maybe we can exchange some thoughts on how to go about it (I am looking at genes putatively responsible for some newborn children diseases such as pyloric stenosis and Hirschsprung's disease).

Keep up the good work.

Alex


User currently offlineANCFlyer From , joined Dec 1969, posts, RR:
Reply 13, posted (8 years 4 months 2 weeks 4 days ago) and read 1665 times:

Excellent!

Very good to hear things are working for you as you'd desire. Of course, I'm sure it's not by accident . . . proper planning and your abilities are obvious the catalyst for your success.

 thumbsup 


User currently offlineSmithAir747 From Canada, joined Jan 2004, 1628 posts, RR: 28
Reply 14, posted (8 years 4 months 2 weeks 3 days 23 hours ago) and read 1647 times:

Quoting Flyingbabydoc (Reply 12):
Congratulations, Frances. I would be very interested in learning more about your research, maybe we can exchange some thoughts on how to go about it (I am looking at genes putatively responsible for some newborn children diseases such as pyloric stenosis and Hirschsprung's disease).

My project (under the tutelage of my supervising professor) will be studying the role of the signalling protein Shh (Sonic hedgehog) and the transcription factor Tbx1 in craniofacial development, and particularly, mutations/errors in Shh signalling and Tbx1 in DiGeorge syndrome (velocardiofacial syndrome).

Thanks for your support! Maybe, in the future we could meet someday!

By the way, my long-term goals would be working in the research of Treacher Collins syndrome (TCOF1) and what goes wrong in order to cause it; there are many "black boxes" and missing links that mystify me in the chain of events that start out as TCOF1 mutations and end up as phenotypic Treacher Collins craniofacial malformations. There is a doctor at the University of Manchester, UK, who found the TCOF1 gene in the early 90s, and I've met him twice, and if the opportunity someday arose, I would like to work with his group.

SmithAir747



I will praise thee; for I am fearfully and wonderfully made... (Psalm 139:14)
User currently offlineLuv2fly From United States of America, joined May 2003, 12110 posts, RR: 48
Reply 15, posted (8 years 4 months 2 weeks 3 days 23 hours ago) and read 1636 times:
Support Airliners.net - become a First Class Member!

Very good news and if any one deserves it I would say you do. Make us proud.


You can cut the irony with a knife
User currently offlineLO231 From Belgium, joined Sep 2004, 2392 posts, RR: 22
Reply 16, posted (8 years 4 months 2 weeks 3 days 21 hours ago) and read 1608 times:

Very good news, congrats!

You seem to be a very hard working, determined man....

Way to go!  bigthumbsup 

Regards,
LO231



Got both LO 788 frames already, next LO E95 and 734 BRU-WAW-BRU
User currently offlineLHMARK From United States of America, joined Jan 2000, 7255 posts, RR: 46
Reply 17, posted (8 years 4 months 2 weeks 3 days 21 hours ago) and read 1597 times:

That is awesome, Francis. I can tell you're going to be a mountain-mover in your field. I hope you find those 8 weeks very fulfilling.


"Sympathy is something that shouldn't be bestowed on the Yankees. Apparently it angers them." - Bob Feller
User currently offlineFlyingbabydoc From , joined Dec 1969, posts, RR:
Reply 18, posted (8 years 4 months 2 weeks 3 days 19 hours ago) and read 1569 times:

Quoting SmithAir747 (Reply 14):
My project (under the tutelage of my supervising professor) will be studying the role of the signalling protein Shh (Sonic hedgehog) and the transcription factor Tbx1 in craniofacial development, and particularly, mutations/errors in Shh signalling and Tbx1 in DiGeorge syndrome (velocardiofacial syndrome).

Well, good luck on that one. I find signalling pathways rather tricky to work with. We did an extensive experiment on the NOTCH pathway disruption caused by a t11;19 translocation in a lung tumor, only to get even more confused down the line. So many interactions! Turns out it works through a completely pathway (CREB - cAMP). 6 Months for nothing. But I am sure you will be more "on target" than I was!

Quoting SmithAir747 (Reply 14):
Thanks for your support! Maybe, in the future we could meet someday!

I would like that. We treat surgically a lot of children with cranio-facial deformities (scaphocephalus, schizocephalus, to name a few). I would be very interested in joining clinical knowledge to ground research such as the one you are doing. And, who knows, we might even be moving to the UK in the future. Maybe we will actually work together.

Quoting SmithAir747 (Reply 14):
By the way, my long-term goals would be working in the research of Treacher Collins syndrome (TCOF1) and what goes wrong in order to cause it; there are many "black boxes" and missing links that mystify me in the chain of events that start out as TCOF1 mutations and end up as phenotypic Treacher Collins craniofacial malformations. There is a doctor at the University of Manchester, UK, who found the TCOF1 gene in the early 90s, and I've met him twice, and if the opportunity someday arose, I would like to work with his group.

That is way more like my current research. Will you be looking at the genomic sequence of TCOF1? finding mutations is rather easy with a capillary sequencer, however going from the mutation into protein mutation and further into phenotype derivation requires a huge number of patients and families. You would be better off reconstructing haplotypes (loss-of-heterozigosity studies) in order to associate the genetic changes with the phenotype. I can help you with that if or when the time comes.

I can only say that you are truly entering a thrilling, exciting field and I cannot encourage you enough to continue on that path. As I said, should you ever need any help (or even an internship in our lab), just let me know. You can see the management of the craniofacial abnormalities "in the flesh" and perhaps start working on some nice DNA sequencing.

Best of luck, keep in touch.

Alex


User currently offlineSmithAir747 From Canada, joined Jan 2004, 1628 posts, RR: 28
Reply 19, posted (8 years 4 months 2 weeks 3 days 19 hours ago) and read 1551 times:

Quoting Flyingbabydoc (Reply 18):
As I said, should you ever need any help (or even an internship in our lab), just let me know. You can see the management of the craniofacial abnormalities "in the flesh" and perhaps start working on some nice DNA sequencing.

Thanks! I'll keep that in mind!

Hope you do get to come to the UK! The research facilities in London (King's College London-Guy's Hospital) and Manchester (Univ. of Manchester), at least, are pretty near the top in the craniofacial field.

SmithAir747



I will praise thee; for I am fearfully and wonderfully made... (Psalm 139:14)
User currently offlineFlyingbabydoc From , joined Dec 1969, posts, RR:
Reply 20, posted (8 years 4 months 2 weeks 3 days 18 hours ago) and read 1536 times:

Quoting SmithAir747 (Reply 19):
Hope you do get to come to the UK! The research facilities in London (King's College London-Guy's Hospital) and Manchester (Univ. of Manchester), at least, are pretty near the top in the craniofacial field.

Thanks. I might look into that, although my area would be more neuroscience -control mechanisms of respiration and digestive system. These are just ideas for the future for now...  Wink

Alex


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