As I've stated in another thread, the F-22's future may be in doubt. There are 3 new strike/fighter programs in the US... the F/A-18E/F, F-22, and JSF. The F/A-18E/F is definately going to happen as it is far along, money has been appropriated, and is necessary for the Navy to have something to replace the F-14 and fill the strike roll of the A-6, along with possibly the role of the EA-6B. Now, the problem is, the DoD/Government doesn't have enough money for both the F-22 and JSF, so, more than likely, one is going to be cut.
About the only thing out there in mass service that the US would face in combat that can beat the F-15C, F-16C, or F/A-18E is the Su-27 and its derivatives. I personally feel that the F/A-18E and the F-15C (if it were to be given avionics upgrades) are pretty much on an equal plain with the Su-27...that kind of makes the F-22 one really expensive item that isn't totally needed.
So, I personally see the F-22 being put on hold or purchased in very small numbers, with the F-15 and F-16 continuing to be the current front line fighters until potential enemies get ahold of aircraft along the likes of the Su-37.