Ok, before anyone tries to be funny, let's get this out of the way.
Do you have a preference between knobs and handles? I surely prefer handles. Here's why:
-knobs are just boring.
-knobs tend to break
-knobs are ugly
-knobs aren't stylish (yeah, I'm sure there are some cool knobs around, but in general)
-handles give you a firmer grip
-handles are attached at 2 points rather than 1, making them more stable.
-handles in general are more versatile
Sure, there are some downsides to handles...
-you can get your hand stuck in the handle
-wood handles can give you splinters if not maintained properly (the onus here, of course, is on the owner for proper maintainance)
-you have to wrap your hand around the handle where with knobs you can just grab
Right now my dresser has knobs. They were cheaper.