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HAWK21M
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Any Vaccines For Malaria

Sun Nov 13, 2005 7:06 pm

Is there any vaccines Available to fight off Malaria.
If not Why.
Currently its the Spraycan,Cream tube or The Mosquito net.Any other protection & preventive methods.
regds
MEL
I may not win often, but I damn well never lose!!! ;)
 
MD11Engineer
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RE: Any Vaccines For Malaria

Sun Nov 13, 2005 7:13 pm

Malaria is a parasitic disease caused AFAIK by several types of protozoa. During certain stages of their lives they have to be inside an Anopheles mosquito, at others inside human blood cells and the human liver.

AFAIK, there are experiments going on to create a vaccine, notably in Cuba, but no vaccine exists yet.

There exist several chemotherapeutica / prophilactica, like the old quinine (still considered the most powerfull one, but has bad side effects on the liver), Paludrine, Resochine etc., but depending on the region, several strains have become imune to them.

Jan
Je Suis Charlie et je suis Ahmet aussi
 
iakobos
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RE: Any Vaccines For Malaria

Sun Nov 13, 2005 7:44 pm

Jan is correct.
There are excellent prophylactics available nowadays, Lariam and Mefloquine are widely and successfully used....by those who can afford it.
 
EZEIZA
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RE: Any Vaccines For Malaria

Sun Nov 13, 2005 11:59 pm

When I was in Africa I was given Lariam but I only took it for a few days after so many people told me it was useless if I was going to stay for a long time (originally 5 months, ended up staying 3) and that the side effects were awful. Therefore I decided to take nothing, and I did not get malaria  Smile
Carp aunque ganes o pierdas ...
 
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HAWK21M
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 2:20 am

Quoting EZEIZA (Reply 3):
the side effects were awful

Like what.
regds
MEL
I may not win often, but I damn well never lose!!! ;)
 
cha747
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 7:26 am

Hey Mel,

If you do a search for "mefloquine" you will see some of the "awful" side effects. There have been several anecdotal cases in the media of patients having vivid hallucinations and even several stories of suicide associated with taking mefloquine, but as far as I know, there are not much medical evidence for this.

Malaria is like tuberculosis. It is a disease that is confined primarily to poor(er) nations and affects those who really cannot afford these expensive drugs. The drugs that have been produced are technologically outdated. In America, we are using 100 year old technology to even make the diagnosis; no lab company will make a "quick" test that is based on new technology becuase malaria is such a rare diagnosis, they could not make a profit. Poor(er) countries will not be able to afford these tests. There are conspiracy theories that drug companies will make more money selling anti-malarial pills to paranoid people who can afford it, than they will selling a vaccine that could save thousands of lives to people who cannot afford vaccines (sorry if that sentence didn't make any sense).

Hope this helps.

P.S. Where is Mendis?
You land a million planes safely, then you have one little mid-air and you never hear the end of it - Pushing Tin
 
ctbarnes
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 9:19 am

The test for malaria is quite simple, involving the technologist looking at a smear of blood under a microscope. It is also successfully treatable, with medications available to eradicate the parasites in the blood, and also kill it in the liver to prevent reoccurance (Malaria spores collect and incubate in the liver for 30 days and when they mature they re-enter the bloodstream all over again.

Researchers have been attempting to isolate an anti-malaria vaccine for about 10 years now, and have not had much success. I think it has to do with the parasites continuing to mutate, and the new strain may well be immune to the vaccine.

The thing to remember is that prophylactics like Cloraquine or others do not actually prevent malaria, they merely suppres the symptoms. The best way to prevent malaria is to wear long sleeve shirts and trousers from dusk to dawn (when malaria-carrying mosquitos come out), as well as a good insect repellant. Make sure you check with your doctor regarding whether you should also take a prophylactic. With the more serious strains of cerebral malaria out there it can mean the difference between life and death.

Charles, SJ
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aloges
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 9:27 am

Quoting Cha747 (Reply 5):
Malaria is like tuberculosis. It is a disease that is confined primarily to poor(er) nations and affects those who really cannot afford these expensive drugs.

Naah... not that many cases of Malaria in Russia, are there? The tropical countries where Malaria strikes worst just happen to be the poorer countries on Earth; certainly availability of medication makes things worse but Anopheles usually stays in warm climates. Then there are some cases of "airport Malaria" when Anopheles plays stowaway and stitches people in the airport area.

Quoting Cha747 (Reply 5):
P.S. Where is Mendis?

say, "on a long vacation"
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EZEIZA
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 1:05 pm

Quoting HAWK21M (Reply 4):
Quoting EZEIZA (Reply 3):
the side effects were awful

Like what.



Quoting Cha747 (Reply 5):
There have been several anecdotal cases in the media of patients having vivid hallucinations and even several stories of suicide associated with taking mefloquine, but as far as I know, there are not much medical evidence for this.

I had no side effects since I only used it for a short time, but to add, I was told that lariam also creates sleeping problems and screws up the liver. Again, this is only what I was told but I was never able to test myself, but just in case I stopped using it.
Carp aunque ganes o pierdas ...
 
N1120A
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 1:16 pm

Quoting Cha747 (Reply 5):
P.S. Where is Mendis?

In Ghana and banned.
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ctbarnes
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 1:17 pm

Quoting EZEIZA (Reply 8):
I had no side effects since I only used it for a short time, but to add, I was told that lariam also creates sleeping problems and screws up the liver. Again, this is only what I was told but I was never able to test myself, but just in case I stopped using it.

Lariam was supposed to be the magic bullet that would take care of the most severe forms of malaria, but unfortunately it did not work out that way. There was controvercy in the 1990's Roche had underreported the severity of side effects up to and including serious mental problems that develop as a side effect. When I was in Africa in the 1990's I tried taking Lariam, and it worked OK for two weeks, but had to go off it after a severe bout of nausea after taking the drug for a second time. After that I returned to the more trusted Chloraquine/Proguinil combination I had been taking before.

I contracted malaria twice in the year I spent in Nigeria. Both times I took Fansidar to treat it, plus Proguinil the second time to kill the spores in the liver. Symptoms disappeared within the hour.

Charles, SJ
The customer isn't a moron, she is your wife -David Ogilvy
 
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HAWK21M
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 2:00 pm

Quoting Cha747 (Reply 5):
P.S. Where is Mendis

Working in Ghana.Currently in Japan.

Quoting Ctbarnes (Reply 10):
I contracted malaria twice in the year I spent in Nigeria. Both times I took Fansidar to treat it, plus Proguinil the second time to kill the spores in the liver. Symptoms disappeared within the hour.


Its normally confused with the Dengue fever symptoms.
regds
MEL
I may not win often, but I damn well never lose!!! ;)
 
flyingbabydoc
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RE: Any Vaccines For Malaria

Mon Nov 14, 2005 7:49 pm

Quoting MD11Engineer (Reply 1):
AFAIK by several types of protozoa.

Correct. Plasmodium sp. with several subspecied (Vivax, falciparum - the most dangerous)

Quoting Iakobos (Reply 2):
excellent prophylactics available nowadays, Lariam and Mefloquine are widely and successfully used

Unfortunately in many areas (like Brazil) the widespread use of these drugs as "prophylaxis" has lead to resistant strains (particularly of P. falciparum) that are not sensitive to Mefloquine or Lariam anymore. I agree that not getting bit is the best prophylaxis

There is a good review from 2000 in this link:

http://www.biomedcentral.com/1523-3820/2/266

Cheers

Alex
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TACAA320
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RE: Any Vaccines For Malaria

Thu Nov 17, 2005 11:01 pm

Here is no vaccine for malaria
available by the moment. As malaria is a
parasitic disease caused in humans due
to four different species of
Plasmodium it is very difficult to
create a vaccine that is good for all
types of Plasmodium, there has been
efforts done like the Patarroyo
vaccine in Colombia but it is only
against one type and the immunity
given does not last too much.
'Science without religion is lame, religion without science is blind'. Albert Einstein
 
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HAWK21M
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RE: Any Vaccines For Malaria

Sat Nov 19, 2005 11:47 pm

Is there any research on to eliminate the mosquito.
regds
MEL
I may not win often, but I damn well never lose!!! ;)

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