I don't know your preferences or thoughts about Las Vegas (or if you have ever been before, etc.)
I decided to write down a few of my thoughts on Sin City that hopefully you'll find useful.
Where to stay. The Strip is where the action is, but just about any hotel (and convenience store, pharmacy, the airport, etc.) have slot machines and other types of gaming. For me, I want to stay on The Strip (unless I'm interested in the Hard Rock or the Rio, which are a few blocks away). I can't speak for all hotels on The Strip but I would think that very few of them offer airline crew discounts. The hotels that are generally used by airline crews for stay overs, etc. (and would potential offer discounts) are not going to be on The Strip and could be inconvenient.
Most places on The Strip are fairly reasonable midweek. Some of my recommended places are the Luxor (typically $80-90 per night, midweek), or MGM Grand, Monte Carlo, Paris, all of which start getting a little more pricey. If you are only interested in high end hotels, then Caesars Palace and Wynns are great places, but one cannot forget about The Venetian, of my favorite hotels in Las Vegas! Worthy of note is that if you stay at the Luxor, be sure to ask for a room in the Pyramid, otherwise you might find yourself in the non-descript tower next to it.
Of course, there are places cheaper than The Luxor on The Strip and basically you get what you pay for. I will say that with prices as low as they are in Vegas, having an airline discount is almost pointless. If you are planning to stay for a Friday or Saturday night, however, be aware that there are very few cheap rooms! That $79 room at the Excalibur might jump to $259! My advice when booking a room is to do the traditional search on Expedia or Travelocity, find a good price, then go directly to the hotel's website to see if you can better it.
Las Vegas is, without doubt, unique. It is the one place in the USA - if not the world - where truly anything goes. You have a complete mix of people ranging from Hummer-limo rap singers with cash to the excess all the way down to homeless bums that don't have two dimes to rub together. Throw in the fact that this oasis is in the middle of the desert with oven-like temperatures over the summer, and it makes it even more surreal! Strip clubs, restaurants, helicopter tours of the Grand Canyon, roller coasters at three different casinos: Vegas has something for everyone! And everybody wants you to spend your money!
If you have a chance, I also recommend renting a car and driving away from Las Vegas for a while. Take a break and drive to Hoover Dam or, if time is no issue, Zion National Park is about 90 minutes a way in southern Utah. Truly an amazing and magnificent place!
I don't know if this helped at all. I'm sure you are a well-traveled person but I wish you the best of luck and hope you enjoy the Las Vegas area.
None shall pass!!!!