dtwclipper
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Breakthrough In HIV Vaccine

Thu Sep 24, 2009 2:14 pm

Combo vaccine reduces risk of HIV infection, researchers say

http://www.cnn.com/2009/HEALTH/09/24/hiv.vaccine/index.html


While it looks promising, it still is in the early stages, and of course does not help the millions of HIV+ people nor the 2 million who still die every year from it.
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seb146
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 3:34 pm



Quoting Dtwclipper (Thread starter):
While it looks promising, it still is in the early stages, and of course does not help the millions of HIV+ people nor the 2 million who still die every year from it.

Even from that, they could make a vaccine or some kind of medication for people already infected, so this is a huge step. This shows we are getting closer to a cure for this, too.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 3:46 pm



Quoting Seb146 (Reply 1):
some kind of medication for people already infected,

We have that already, the triple cocktail combinations hold off the replication of the virus and keeps it in a non-detectable level in the blood. However, HIV is a nasty bug and hides in the lymphatic system and other little spots.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 3:46 pm

This is a mixed blessing - HIV is one of the few disease scourges that has been statistically shown to drive down population growth numbers in many developing nations. If the vaccine release, once its mature, can be correlated to government-mandated contraception in many such societies, then it will be a different story entirely.
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ManuCH
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 3:49 pm

That's interesting. But something makes me think:

Quote:
Fifty-one people in the vaccine group eventually contracted HIV, compared with 74 in the placebo group.

Does this actually mean that 16000 people took the trial vaccine (or the placebo), but were so poorly informed about HIV that they managed to get infected anyway? 125 people out of a sample of 16000 is a lot!
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N104UA
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 3:54 pm

I was really happy when I read this this morning, HIV/AIDS is one of those viruses that many people in many countries are not too worried about. I am glad this happened but surprised that it happened in Thailand and not the USA or Europe.

Quoting ManuCH (Reply 4):
Quote:
Fifty-one people in the vaccine group eventually contracted HIV, compared with 74 in the placebo group.

Does this actually mean that 16000 people took the trial vaccine (or the placebo), but were so poorly informed about HIV that they managed to get infected anyway? 125 people out of a sample of 16000 is a lot!

It was 16,000 total in the trial with a little over 8,000 getting the placebo and a little less than 8,000 getting the vaccine

The Huffington Post has a better article on it
http://www.huffingtonpost.com/2009/0...-vaccine-helps-preve_n_298250.html
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 4:15 pm



Quoting Dtwclipper (Reply 2):

We have that already, the triple cocktail combinations hold off the replication of the virus and keeps it in a non-detectable level in the blood. However, HIV is a nasty bug and hides in the lymphatic system and other little spots.

The problem with this is compliance. If people lose their insurance and can't afford these drugs, then they develop resistance. And a multi-resistant bug is a horrible thing to manage.

This is a major breakthrough, since this is the first HIV vaccine that has shown ANY effectiveness at all. However, it appears to be only a 30% reduction in risk. I'm concerned that, in its current state, such a vaccine could INCREASE infection rates by giving people a false sense of security and discouraging condom use.
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dtwclipper
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 4:19 pm



Quoting DocLightning (Reply 6):
This is a major breakthrough,

Agreed, but what does this do for those already HIV+?

Is a vaccine the road to "curing" those already infected?
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 4:23 pm



Quoting Dtwclipper (Reply 7):

Agreed, but what does this do for those already HIV+?

Is a vaccine the road to "curing" those already infected?

If it teaches us something about the way the immune system can be trained to handle the virus, then yes. Perhaps it won't directly help, but it can help.

Also, suppose that tomorrow, a 99% effective vaccine became available. It might not help those who are currently living with the disease, but it will prevent anyone new from contracting the illness. In 30 years, HIV could be eradicated from the world. What a wonderful thing that would be.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 4:47 pm



Quoting N104UA (Reply 5):
I am glad this happened but surprised that it happened in Thailand and not the USA or Europe.

Don't be. Thailand has an HIV problem and they are doing what they can to fight on all fronts. In the US and the EU the drug companies make a nice buck from ARVs so the status quo (treatment over prevention) is accepted.

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ManuCH
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 5:23 pm



Quoting N104UA (Reply 5):
It was 16,000 total in the trial with a little over 8,000 getting the placebo and a little less than 8,000 getting the vaccine

Yes, I've read that. But my question remains: 16,000 took part in the trial, and 125 got infected. That's too many people to get infected, especially because they took part in the trial! They're supposed to be people who know what HIV is about (I think those who administered the vaccine/placebo explained it first!), and still they took such a risky behavior in their lives that 125 of them got the virus.

My complaint isn't about the trial itself, but the fact that too many people still get HIV even though they are informed about the risk factors.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 5:37 pm



Quoting YOWza (Reply 9):

Don't be. Thailand has an HIV problem and they are doing what they can to fight on all fronts. In the US and the EU the drug companies make a nice buck from ARVs so the status quo (treatment over prevention) is accepted.

It's also a coup for Thailand. The U.S. has touted its superior medical sciences forever. We still spend more public money for R&D grants than any other country in the world, per capita. Thailand is not known for its major contributions to modern medicine, but this is a huge, huge feather in Thailand's cap.

BTW, the drug companies don't make nearly the money from ARV's that they do from, say, VIAGRA or from even cholesterol or BP drugs. They actually do the ARV's because they're drug companies and, although they like to make money, they are also interested in helping patients in the process. The actual number of HIV people in the U.S. is quite low, by the standards of an infectious disease. Even in a place like San Francisco, the prevalence is shockingly low. It's not like poor places in Africa.

If someone, including a drug company, comes up with a vaccine, it will be available to the entire population and it will be wildly, WILDLY successful, paid for by the government and governments all over the world. I believe that the profit from an effective vaccine would completely overwhelm any paltry earnings that even new drugs like FUZEON or ISENTRESS are making. And, most likely, the vaccination would eventually become like the HBV vaccine: a recommended/mandatory childhood vaccine.

So I think there is an enormous financial incentive for a US company to come up with an effective HIV vaccine.

However, I predict that any such effective vaccine will require multiple doses and perhaps boosters. Or that it might become like the flu shot and, in order to keep up with mutations, be required every year.
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dtwclipper
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 5:52 pm



Quoting DocLightning (Reply 11):
It's also a coup for Thailand. The U.S. has touted its superior medical sciences forever.

It is really a joint effort.

"The study was funded by the National Institutes of Allergy and Infectious Diseases and the U.S. Army Medical Research and Materiel Command.

According to Kim, the U.S. military was involved in the study because U.S. service members are at risk and "there's a national security threat from HIV."
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 5:53 pm

I dont think there will be a vaccine in my lifetime that will halt HIV. Basically it is and still will be a death sentance.
 
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 5:57 pm



Quoting OA260 (Reply 13):
Basically it is and still will be a death sentance.

Hardly. With med compliance the mortality rate is now on par with the general population.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:01 pm



Quoting OA260 (Reply 13):
Basically it is and still will be a death sentance.

Well, life itself is a death sentence. No one's getting out of here alive. I guess if you can just slow things down beyond your natural death, then it is as good as cured, right?

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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:01 pm



Quoting OA260 (Reply 13):


I dont think there will be a vaccine in my lifetime that will halt HIV. Basically it is and still will be a death sentance.

In the sense that diabetes is a death sentence. HIV and diabetes carry similar mortality and morbidity at this point. The difference is that you don't catch diabetes from anyone (that we know of, although infectious triggers keep getting proposed by various investigators).
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:07 pm



Quoting ManuCH (Reply 10):
Yes, I've read that. But my question remains: 16,000 took part in the trial, and 125 got infected. That's too many people to get infected, especially because they took part in the trial! They're supposed to be people who know what HIV is about (I think those who administered the vaccine/placebo explained it first!), and still they took such a risky behavior in their lives that 125 of them got the virus.

Well they did not infect them with the virus they gave them the vaccine or placebo and watched them for 3 years so these people who got the disease did not change anything about their lives so they would have gotten it anyways

Quoting OA260 (Reply 13):
I dont think there will be a vaccine in my lifetime that will halt HIV. Basically it is and still will be a death sentance.

It is not really a death sentence now as it was in the early 1990s they can control HIV with meds and remember the HIV is not AIDS, but HIV can lead to AIDS. And remember in the 1940s we thought polio was a death sentence and same thing with small pox and they are really non-existent any more. Science is growing exponentially every day, I believe that we will see it gone by 2030.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:19 pm



Quoting N104UA (Reply 17):
Well they did not infect them with the virus they gave them the vaccine or placebo and watched them for 3 years so these people who got the disease did not change anything about their lives so they would have gotten it anyways

I guess I'm having trouble expressing myself today  Smile

I know that they didn't infect them with the virus. I expect people informed about HIV to conduct such a lifestyle that minimizes infection risk. And I expect people being given a trial vaccine to be informed about HIV just enough to know what not to do in order to avoid getting it. 125 people out of 16,000 is 0.78%. That's a lot, and it sounds like these people were *not* informed about the risks of HIV - or they were ignoring the information.

Or did they actually administer the trial vaccine (or placebo) without explaining anything, as in "here's a shot for you, I won't tell you what it's good for"? I can't believe it...
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:19 pm



Quoting N104UA (Reply 17):
It is not really a death sentence

I had a friend in London who told me that 9 years ago.

Quoting N104UA (Reply 17):
but HIV can lead to AIDS.

Thats what happened to him and he is dead now


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dtwclipper
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:23 pm



Quoting OA260 (Reply 19):
Quoting N104UA (Reply 17):
It is not really a death sentence

I had a friend in London who told me that 9 years ago.

Quoting N104UA (Reply 17):
but HIV can lead to AIDS.

Thats what happened to him and he is dead now

I'm sorry to hear that. Was he/she med compliant?

I know people who have been HIV+ since the 80's and are still going strong and are very healthy.
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:29 pm



Quoting Aaron747 (Reply 3):


This is a mixed blessing - HIV is one of the few disease scourges that has been statistically shown to drive down population growth numbers in many developing nations. If the vaccine release, once its mature, can be correlated to government-mandated contraception in many such societies, then it will be a different story entirely.

I agree that saving lives always raises the issue of what to do with those lives. However, if we can discover a cure or a vaccine then we are ethically obligated to do it.

Mandatory contraception is a rather draconian rule that will be difficult to use in countries where there is a strong ethos of childbearing. For example, in Mexico (which I choose simply because I know so many Mexicans from rural, farming communities not unlike those in Africa), it isn't so much Catholic fervor that encourages huge families, but social pressures in general. For a rural Mexican farm boy of 16 who has just been married, one way he has to prove his manhood is by ensuring that his wife is pregnant early and often. He might not give a crap about what the Priest says, but he sure cares about what the other men in his community say, because he's a young man and young men feel a lot of pressure to show their manliness.

Similarly, a girl of 16 feels a lot of pressure from the older women in her community to tow the line and make tons of babies. Especially because she really doesn't get offered much of a choice.

Yes, having a lot of kids gives you a lot of hands for the farm and ensures that you will be taken care of in your old age. But young men respond very strongly to any challenge to their masculinity. Young women respond very strongly to admonitions about motherhood and matriarchy. We can use that to our advantage in the education system.

You can't change such a culture with mandatory contraception, but with education and healthcare, you can do exactly that. Alter perceptions to young men that a man's job is to not be a father until he has an education and can support his family. Alter perceptions to women that there are other options than being a teenage mother and a stay-at-home mother of 8 children.

Technology alone can solve a lot of problems, but without responsible sociology to go with it, it causes a lot of them, too.
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OA260
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 6:59 pm



Quoting Dtwclipper (Reply 20):
I'm sorry to hear that. Was he/she med compliant?

To be honest I dont know. We were friends for years and then drifted apart. I think he had some issues and cut people off and became a bit of a loner so it was not my decision and I can understand his reasons but only found out recently. I do kind of count my blessings that I didnt have to see him towards the end and I know that sounds bad but I dont think I would cope well at all. He was a great character though and Im glad I can remember him the way I want to.

God forbid I ever got HIV and got full blown AIDs and got really sick I would go to Switzerland and commit suicide. Thats just me personally. Same way if I ever got any other terminal illness. I know its not for everyone but i wouldnt want to be looked after by anyone.

And to think there are people that deliberately go out and get infected.
 
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 7:12 pm



Quoting OA260 (Reply 19):

I had a friend in London who told me that 9 years ago.

And you don't know about his case or how well he took care of himself. It's not a death sentence, but like diabetes, if it's not cared for, it's deadly.

It's hard to be a motivated patient when taking your medicine doesn't necessarily treat a symptom that you have. People stop, forget, go into denial and decide that they're cured...
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 7:57 pm



Quoting DocLightning (Reply 23):
how well he took care of himself.

All I know is the years I knew him he was gym fit and big into nutrition and never ate bad food or junk food. Whether that changed in the last days who knows. As I said Im not sure what meds he was on but he was attending the hospital for check ups. He was doing that when we were still socialising. I remember the day he told me he was HIV+ . Was like a car dropping on me from above. Remember feeling guilty because I was close to tears and upset when it was him that had to deal with it. I had been totally sheltered from this issue until then. It never changed my views or opinions about him though and he was always ''Keith'' my friend.
 
UAL747
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 8:40 pm

I'm very happy to see that HIV hasn't become so taboo to discuss openly without the usual drivel on would expect just a few years ago.

My great uncle died of AIDS back in the 80's. My family told everyone he had cancer because of embarrassment. I thought he had cancer until I came out at 21 and my grandmother found it an appropriate time to tell me about it, for her own reasons I believe.

I hope someday we find a cure for this. But I hope in that quest for a cure, people don't become complacent about their own sexual health.

Sex is part of a healthy lifestyle, and it should be practiced, and I feel sorry for anyone who is denied that part of their lives. There's no blame to be passed on those that have it, but only lessons for those who don't. It's common sense in the 2000's that you need to protect yourself if you have not been tested and are not monogamous.

The problem with HIV is that people do not have symptoms of HIV infection and it has such a long latency period, that an extremely sexually active person could infect so many people in such a short amount of time.

Also, there is the fear of the test itself. I feared my first one so much, until I had some counseling about it and understood that the disease is manageable, and got some of the stereotypes I had in my mind about the disease addressed by a doctor.

I know that there are some swab tests for the mouth, but I had a blood test done. Not sure what the difference is here, but that's what they did. Fortunately, I'm negative, but I think knowing that IF something were to come back positive for any reason, it's manageable, I feel less worried about being tested. If that makes any sense.

But, it's so important that you get tested because you could be infecting others and not even know it.

At any rate, the above news is very good indeed!
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 9:16 pm



Quoting Ual747 (Reply 25):
Also, there is the fear of the test itself.

Yes the first time I had one I wasnt even in the Doctors for that and she asked if I had one. She knew I was Gay and therefore suggested it. So it was kind of easier as it was a snap decision and I was in her office anyway. Until I got the results though I was really worried and at one stage nearly convinced myself of the results. When I got the all clear it really was an amazing feeling. I had been playing it safe anyway but still it was stressing me.
 
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RE: Breakthrough In HIV Vaccine

Thu Sep 24, 2009 10:48 pm



Quoting Ual747 (Reply 25):


The problem with HIV is that people do not have symptoms of HIV infection and it has such a long latency period, that an extremely sexually active person could infect so many people in such a short amount of time.

Actually, I learned a few months ago during an expert by one of our HIV specialists that typically, they do.

Approximately 80% of patients newly infected with HIV report a "conversion sickness," meaning that they got sick from the acute infection. This is a flu-like or mononucleosis-like syndrome within 7-14 days of the exposure. It goes away and most people assume it was the flu.

During this acute infection period, you have no antibodies against HIV yet and your viral loads are the highest they will ever be. Approximately 90% of new infections are thought to occur while the donor is about to get sick or just got over it.

Obviously, you shouldn't have sex with sick people, but this doesn't mean that sticking to healthy people is safe. You don't know if that partner is just about to get sick the next day. In other words, keep wrapping it before you use it.
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N104UA
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 12:27 am



Quoting ManuCH (Reply 18):
125 people out of 16,000 is 0.78%

but if you figure that Thailand has 1.05% of the adult population with HIV, and that 51 out of 8,197 people given the vaccine got HIV that is 0.62% and 74 out of 8198 given the placebo that is 0.90%. That means that people with the vaccine have a 32% less chance of having HIV and if it was in Swaziland where 26% of the population has HIV and if everyone were given the shot that would be down to 17% of the population.

Quoting ManuCH (Reply 18):
That's a lot, and it sounds like these people were *not* informed about the risks of HIV - or they were ignoring the information.

They were informed but everyone has a chance of getting HIV and I believe that they were informed like people in the USA or Switzerland are but people still get it. So this vaccine might have saved 23 people from getting HIV.
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 1:04 am



Quoting Dtwclipper (Reply 7):

Agreed, but what does this do for those already HIV+?

Is a vaccine the road to "curing" those already infected?

Can be. That said, if we can combine a vaccine with the drug therapies already out there, hopefully we can eventually wipe out the disease while allowing those who have already contracted it to live full and healthy lives.
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 1:33 am



Quoting Dtwclipper (Reply 20):
I know people who have been HIV since the 80's and are still going strong and are very healthy.

Indeed there are. I've read that there have been studies regarding this that have shown that some people have a genetic predisposition which makes it so that HIV cannot attack their immune system as readily as it does to those without the predisposition. Still that there are those living today who were diagnosed at a time when the mortality rate was very close to 100% always amazes me.

Quoting OA260 (Reply 22):
God forbid I ever got HIV and got full blown AIDs and got really sick I would go to Switzerland and commit suicide.

Out of sheer curiosity, why Switzerland?
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dtwclipper
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 1:36 am



Quoting OA412 (Reply 30):
Indeed there are. I've read that there have been studies regarding this that have shown that some people have a genetic predisposition which makes it so that HIV cannot attack their immune system as readily as it does to those without the predisposition. Still that there are those living today who were diagnosed at a time when the mortality rate was very close to 100% always amazes me.

You know, I don't know why I'm still here, and yes it amazes me everyday!
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 2:46 am



Quoting N104UA (Reply 5):
I was really happy when I read this this morning, HIV/AIDS is one of those viruses that many people in many countries are not too worried about. I am glad this happened but surprised that it happened in Thailand and not the USA or Europe.

If I remember correctly the last big vaccine trial was done in Thailand. It was run by a South San Francisco company called Vaxgen. The trial failed pretty badly, and there was some back story involving the NIH director. Hopefully this trial fairs better.
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 5:47 am



Quoting Seb146 (Reply 1):
Even from that, they could make a vaccine or some kind of medication for people already infected, so this is a huge step. This shows we are getting closer to a cure for this, too.

They could possible move towards a therapeutic vaccine for people with HIV. What it could do is reduce the pill burden on those already taking meds and while a vaccine may not eradicate the virus with today’s technology it can possibly be more effective than some ARV's healthier and longevity etc...

Quoting Dtwclipper (Reply 2):
We have that already, the triple cocktail combinations hold off the replication of the virus and keeps it in a non-detectable level in the blood. However, HIV is a nasty bug and hides in the lymphatic system and other little spots

Pretty much what I said above. Although I see what your saying is that there is Triple therapy. Keeping in mind “Big Pharma” along with R&D is getting away from combinations or lots of pills nowadays that is part of the success with HAART today. The less pills you have to take then lees toxicity of your body. Not to mention the newer classes of drugs that have been developed since the mid or late 1990’s have less side effects and toxicity for the most part.

Having said all of that it would be a huge step to develop a vaccine that can do pretty much the same thing or even better than what the drugs do with little or no toxicity. Out of the realm of possibility at least for now is a total vaccine that would cure the virus however keeping in mind the Therapeutic vaccine could lead the way for the cure or other developments. Although I don't a cure happening in my life.
 
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 5:59 am



Quoting ManuCH (Reply 18):
I know that they didn't infect them with the virus. I expect people informed about HIV to conduct such a lifestyle that minimizes infection risk. And I expect people being given a trial vaccine to be informed about HIV just enough to know what not to do in order to avoid getting it. 125 people out of 16,000 is 0.78%. That's a lot, and it sounds like these people were *not* informed about the risks of HIV - or they were ignoring the information.

Or did they actually administer the trial vaccine (or placebo) without explaining anything, as in "here's a shot for you, I won't tell you what it's good for"? I can't believe it...

Manu, if I'm understanding what you are saying correctly, I think I can clear up the misconception here.

The 16,000 people that were part of the trial were already HIV positive, the 125 people mentioned are those that went from being HIV positive to having full-blown AIDS.
 
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 6:11 am



Quoting DocLightning (Reply 27):
Actually, I learned a few months ago during an expert by one of our HIV specialists that typically, they do.

Yeah, I guess I should have made myself more clear. Some people do exhibit varying symptoms to varying degrees, however, most doctors would not diagnose it as "conversion sickness," since the symptoms are so classic of other illnesses. Therefore, it's hard to know you have it.

I believe I've read that during the "conversion" period, one is actually more infectious than afterward for a certain period of time. Can you confirm this doc?
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babybus
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 6:14 am



Quoting Dtwclipper (Reply 20):
I know people who have been HIV+ since the 80's and are still going strong and are very healthy.

I was having a chat with a doctor recently and he said that no one dies of AIDS/HIV now.

I didn't believe him ,but then thinking about it ,I don't know anyone who knows anyone who has died from it in the past 10 years.

Maybe it is possible that it can be handled perfectly well with current drugs.
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OA260
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 8:22 am



Quoting OA412 (Reply 30):
Out of sheer curiosity, why Switzerland?

So that I could do one last LX TR !! In all seriousness though ::

This was a BBC documentary and one of the best every made with Julie Watters

http://www.youtube.com/watch?v=ezD0GddG1yM

She has a terminal illness and decides to go to the clinic in Switzerland where she can legally end her life. Its a heart wrenching story but very true to life.
 
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DocLightning
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RE: Breakthrough In HIV Vaccine

Fri Sep 25, 2009 3:20 pm



Quoting Babybus (Reply 36):

I was having a chat with a doctor recently and he said that no one dies of AIDS/HIV now.

Well, you don't generally die "of" it, you die "from," it. To illustrate: if you didn't have AIDS, you wouldn't have gotten the cryptococcal meningitis that killed you. Nobody gets cryptococcal meningitis unless they are severely immunodeficient.

That said, one of my pediatric patients with HIV and Hepatitis B (which she got from a tainted blood transfusion at 4 years old, just before they started screening the blood supply) died at 22 from complications of AIDS. She had a long history of a personality disorder and a difficult adolescence, so she was non-compliant with her ARVs. Her virus became resistant to everything and yet she still refused to be compliant with the new drugs that came out.

And so just after I left residency, I got an E-mail from my former boss that she'd died and inviting me to the funeral. I couldn't go because I was in SF and the funeral was in NYC.

So yes, people do die from complications of AIDS. But not really if they're good about their meds.
-Doc Lightning-

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