When I flew to London I was on a DC-10 (2-5-2). And of course my seat was 28E or something. Its the seat right in the middle. Everyone around me was sleeping when I felt like I had to barf, but the british man who had the isle seat let me take his seat in case I had to make another mad dash to the Lav.!
My sister and I are flying to Rome in December. CO 777 is the A/C supposedly flying us there. 3-3-3 seating. My sister and I purchased a window seat and an isle seat (hopefully CO won't put anyone between us!).
But I agree. Sitting in the middle does suck.