Just to add what Crosswind mentionned, designers try to ensure runways are roughly aligned with the prevailing wind.
However, often envrionmental of physical factors prevent runways from being built into the prevailing wind. Factors such as water, obstacles, noise sensitive areas, etc etc. When this happens, you may find that these types of runways are more succeptable to crosswinds.
But winds being what they are, it's a very inexact science!