United Family Affair: On Oct 29th 1999 Captain Joy Klopfer was the mom flying with her First Officer son Glenn Klopfer on a B767. They were the first mother son cockpit crew.
Lucy and Hedley Tardrew of Virgin Atlantic Airways flew the First Wide-body flight of a married cocpit crew in July, 1996; 747-200; LHR-SFO-LHR
Also, Captain Claudia Jones-Sorenson often flew with her husband, First Officer Fred Sorenson for Southwest Airlines before she took early retirement. He always used to say over the P.A. "This is the First Officer speaking, today your aircraft is under the command of my wife Captain Claudia Sorenson....and yes folks, it's just like at home- She's the boss!"
Interestingly, Claudia and her step daughter Cathy Jones (whom she taught to fly) were the first 'mother & daughter' employed with an airline in the US.