I'm not a professional pilot, but based on my research (I plan on becoming one), here are my opinions.
--away from home a lot... if you work for a mainline carrier, bets are you'll spend just under half of the month in a hotel. I guess that one could swing either way.
--high divorce rate... I've read that professional pilots have a higher than normal divorce rate, probably relating to the being away from home a lot thing.
--takes a lot of time and hard work to get to the majors... plan on spending upwards of $40,000 just getting your education and licenses and such, then working a few years in a really low paying job such as CFI, then work at a regional for a few years making less than $30k... it is definately worth it, IMO...
Advantages (these far outweigh the disadvantages
--it is probably one of the greatest jobs on the planet!!
--pays very well after you've built up seniority... six figures... $$$
--pilots at the majors get decent time off... they work, say, three or four days then get three days off. I like that.
I don't know what else to put... you can probably get a much more comprehensive reply from a pilot than me. Just my input though!
By the way, try contacting Doug Taylor (Delta737 here or catch him at his website, www.jetcareers.com) on this issue and I'm sure he'd love to help you-- or even better the site might answer your questions for you.
Horizon Air - Wings of the Great Northwest