I was on the world's very first scheduled 757 flight--Eastern Airlines from Atlanta to Tampa on January 1, 1983. As a flight attendant I worked the 757 quite frequently from 1983 until 1991 and have flown as a passenger on Delta's 757s many times. My opinion:
Yes, it is a gorgeous, sexy looking aircraft. I always thought it was also quite prehistoric looking; like a pterydactyl. There's nothing that can compare to a full-power takeoff from a tight runway like St. Thomas--the closest thing to a space shuttle launch most of us will ever experience. I don't think the 757 is very comfortable, though. I found it to be very rough riding, especially in the back. Like many long aircraft with wing-mounted engines the tail whips around alot. Also, the ventilation system is very noisy, particularly in the area between the wing and the #2 doors. The closest I ever came to a full-fledged panic attack was sitting near the back of a full Delta 757--I have never felt so cramped and clautrophobic in my life (and it was only relatively short flight from Philadelphia to Atlanta).
I'm sure the 757 is a great money-maker for the airlines but give me the wider seats, wider aisles and quieter cabin of a 717 or MD80 anytime. Overall, though, nothing comes close to a good old 727 for smoothness and comfort.
I work for Southwest, but the views expressed are my own and do not necessarily represent those of Southwest.