I don't think it will. The 757 is now 20 years old, maiden flight was exactly 20 years ago day by day Feb 19 1982, and only 1000 of them have been built compared to over 1800 727's that were built also within 20 years (1964-1984). American recently took delivery of the 1000th 757 built. Even in five years from now the total number of 757 orders won't reach 1800, that I can understand because the NG737's and the A32X, which are the two main narrowbody types in the air transport industry, are being produced in large numbers. True, the 757 was initially designated the successor to the 727, but the NG737's and A320's are also replacing a large number of 727's especially in the United States.
Only two aircrafts in the whole history of civil aviation have beaten the 727: the DC-3 not including the military C-47, and the Classic 737 (100 thru 500 series combined).