According to the head of the wing design team on the A400, Airbus is currently working on the following:
1) An A300/A310 replacement jokingly dubbed A305 by the employees, as they're still specifying and not sure whether it will be closer to A300 or A310 in size, or square in the middle between the two
2) A rather slow, ultra-high capacity freighter for container transport to lure traffic away from container ships.
3) Some supersonic concept planes.
Number 2 sounds a bit like the Boeing Ekranoplan that has been reported on in the press. Number 3 is likely to remain conceptual for quite a while to come. And number 1 - well, sooner or later it's gonna happen, along with the A320 replacement that has been mentioned in the press a few times now (mainly because the EU is directly funding materials development costs for its design)
At Boeing, there's the Ekranoplan thing, the Sonic Cruiser (unless its recent cancellation as reported by the Portuguese press was genuine) and who knows what else.
But honestly, I don't think the freighters or supersonic/transsonic planes are too likely to be seen in the next 20 years.
What do I realistically believe to see in the next 20 years? Mainly replacements for current types. Perhaps a few reluctant steps into Fuselage-wing integration (BWB etc). Main advances are in materials, systems and engines.
Perhaps, in 20-30 years, BWB technology will really take off, with high-capacity airliners to replace the A380 and 747, as well as smaller types with BWB-derived aerodynamic benefits, but still a more conventional structural layout. Perhaps the sonic boom will be reduced and supersonic business jets will become a reality, as well as supersonic ultra-long range aircraft for transpacific transport. But that would be a lot more than 20 years into the future. Perhaps 50...