British Airways will withdraw its loss making services to Plymouth and Newquay from London Gatwick and Bristol airports on 30 October.
However, realising the importance of regional air links to the local community, the airline said it is keen to work with any other parties who may be interested in taking over the routes.
The decision has been made following a fleet and network review by BA
CitiExpress, a wholly owned subsidiary of British Airways. It is part of a full regional review of the business which aims to deliver £20 million cost savings, £7m of which must be achieved during the current financial year.
To provide a more efficient deployment of aircraft, the fleet of 10 BA
CitiExpress Dash 8 turboprops, two of which operate on the affected routes, will in future be based primarily at Manchester where they will operate domestic services. The two Dash 8 aircraft that currently operate services from Southampton will continue to do so.
As a result of the Dash 8 fleet move, the three times a day Bristol to Newcastle service will also be withdrawn although the airline has reconfirmed its commitment to Bristol Airport and the development of its all jet operation there.
David Evans, Managing Director of BA
CitiExpress, said: "A decision to withdraw routes is never an easy one to take and we know how disappointing this is for the people of Plymouth and Newquay. Sadly, we can no longer continue to operate these loss-making services. We will, however, continue to have a strong presence in the south of England at Bristol and Southampton where we have a solid and thriving network of services to Europe and other parts of the UK.
"The fleet and network review was very important for us. It helped us identify where we can make necessary cost-savings and how we can better serve our customers with improved frequencies and schedules elsewhere in our operation."
CitiExpress employs 61 staff at Plymouth and 10 at Newquay.
Customers booked on affected flights will be offered a full refund, and are advised to contact their travel agent.