NW did use the DC-10-30 for the SEA
nonstop run in the mid 1990s without any real issues, but I am not sure if that flight carried much cargo in addition to pax.
To my knowledge, DL
did not fly PDX
nonstop ever, with any aircraft type.......DL
did operate LAX
, first with the L1011-500 with a fuel stop in ANC
, and then nonstop with the MD11.