Southwest Florida, especially the beautiful islands of Sanibel and Captiva, could certainly handle the flight! The airport isn't even an issue, the 12,000-foot runway close to sea level could send a fully-loaded A340 or 747 to Europe any day. The gates on the outside of Concourse A can handle up to a 747, and there is a nice C/I facility just down the hall from the gates. If you haven't been to Sanibel or Captiva, I'd suggest going soon. It really is a great place. In the months of April and July/August, the Lee County area as well as the surrounding area attract large numbers of German and British travelers, with the greatest number connecting through crowded East Coast airports. Fort Myers is also conveniently located for access to other parts of FL. Tampa and Sarasota are an easy drive on a 6-lane highway up the West Coast of FL. Both are under 1.5 hours. This interstate is adjacent to the airport, running parallel to RSW's approach path. The famous Tamiami Trail cuts Fort Myers in half, with access to the road 10 minutes from the airport. Fort Lauderdale and the Palm Beaches are a straight shot down the same interstate from Tampa, a drive of 2 hours. I think European airlines just haven't realized the full potential of RSW as an uncongested US gateway. That is sure to change with the construction of a parallel runway and a large new terminal area in the middle of the runways.
BTW, I am writing this to everyone from Paris right now, I am getting ready to head to the City for the rest of the day with my crew. I am coming back to the States tomorrow on CO55 (764).