Interesting question that you raise. I honestly do not think that we will see any major hubs dropped in the future due to longer-range planes; when the 744, 343, etc were introduced, airlines could eliminate stops in Alaska on Europe-Japan flights, in India or the MidEast for Europe-Asia flights, and in the Pacific Islands on US-Australia flights. But most of these stops where more techinical in nature, the aircraft stopped to fuel and not many pax were interested in the intermediate stopover point.
If new longer-range planes could fly Europe-Austalia nonstop, I do not think we will see diminished service to Singapore, for example, since lots of people want to go to Singapore. I also question how many new routes we will really see: US east cost to Asian cities and US west coast to singapore/kuala lumpur are alway mentioned, but how many other new routes are we really talking about?