Well, they've got 763's going into Fort Meyers from ATL, but this comes from someone who has only been on one widebody, and that was ATL-LGA on a 763, so anything's preferable to some little town that has almost nothing there! However, I can see that you'd like to fly on a 777, 764, MD11, etc..., so I'd just go into Orlando and drive the rest of the way. Or, if it isn't too expensive, you can take the 727 from ROC to ATL, the 777 from ATL to MCO, and an Embraer 120 the rest of the way from MCO to RSW (operated by Comair).
One more thing-- the MD-11's are being sold to UPS in the next 5 years or so... I'd recommend getting on one of those; they're really nice! (From the outside, anyway... sigh)