All four runways handle widebodies.
By far the most common pattern is arrivals on 28L/28R and departures on 1L/1R, except that some departures need more runway so they use 28L/28R.
Arrivals from the east ordinarily use 28R, arrivals from the south and west ordinarily get 28L, and arrivals from the north (and Europe and the Orient) coming in over the Point Reyes VOR might get vectored to either of the 28s, presumably based on which arrival stream (from the east, or from the south) has a handier gap.
Runway 1R is officially 8900 ft, so some departures to Europe use it, but almost all Orient (and most Europe) departures use 28L (10600 ft) or 28R (11870 ft). As they're taxiing out the tower will likely ask them whether they can use 28L or not; if they can they likely will, but many pilots request (and get) 28R.
As you would expect runway 1L is usually used by the departures that are going to turn left after takeoff to head down the coast-- which, as it happens, very few widebodies do. But I've seen Nippon Cargo 747s to LAX take off on 1L (which is officially 7000 ft, but actually around 7700 ft).
When the wind changes widebodies land on 19L-- can't say how often one accepts a landing on 19R. Widebodies have been known to depart from both 19L and 19R on rare occasions.
Far as I know widebodies can land or take off from either 10L or 10R.