Flying two-pilot airliners with a single pilot would not be too big a deal - as long as everything is working properly. After all, the military has been flying high performance multi-engined jet aircraft with single pilots for decades. As far as corporate aircraft go, there are plenty of bizjets that are certified for single-pilot operations. As to whether or not this is wise is a topic for another discussion. From my own experience, I can add two points. First, way back when I worked for a major, I had the chance to fly a 727 simulator single-pilot. It actually was possible. You had to position yourself near the FE's panel for the engine start after which you went to the captain's seat. Only if you needed to balance fuel was it necessary to get out of the pilot's seat - but then, that's what auto pilots are for right? Finally, a few years I go I was on a trip to Bolivia and the other pilot I was with became desperately ill. It was literally a matter of life and death. Time was extremely critical, he had only a very few hours to get the proper antibiotics to save his life. There were no qualified pilots available locally and we had no time to wait for a replacement pilot to arrive from the States. We put him in the airplane and I flew it single-pilot to Texas. Although, our aircraft require two-pilot crews this was really a non-event as far as the flying part went.