There is a one way route between Sicily and Malta !!!
It is southward !!!
If you have the Jeppesen 7/8 chart,you can notice the
one way route UA96 from Carbonara CAR to Tunis TUC via NOLSI,GOTUS,and PORTO ! It is used only for traffic landing at Tunis,and the GOTUS,PORTO,TUC track straight in Tunis' Rwy 19 axis !!!