Dear Chris -
I have no recent specific info about the schedules of a typical Fedex pilot. As you stated, there is a marked difference with flying US domestic routes, or international. Maybe you do not fly sundays and holidays, but... you may be stuck away from your homebase, which is not necessarily Memphis...
Air cargo crews do have schedules just about same as passenger airline pilots and believe me, "cargo flying" is a rather pleasant experience. These carriers, such as Fedex, UPS or... Cargolux pay well, if not sometimes... more than some passenger air carriers. After my many years with PanAm, I enjoyed one year with Cargolux, after PanAm's bankruptcy... It was a well run operation, on the clock, and in case of delays... cargo does not need hotel rooms... moreover, when the economy goes bad, people do not travel as much, but the shipping of cargo does not change much.
Strictly thinking of future pilots reading these lines, I would suggest they look closely at air cargo operations... before they make a choice of an airline. As far as time home, it is about the same. With PanAm, with Cargolux, and now here in Argentina, I am basically home 10 days a month when flying schedule, of course, with my activity in the training department, I am often at home for the night when I work in classrooms or office... when in simulators, I have to be away in the USA or Europe for a few days, as if I was flying. Domestic pilots are more often at home at night, but sometimes work more days per month...