At most airports, controllers know which planes park where, and obviously which direction they're arriving from, and will try their damndest to get them to the most convenient runway, without the pilot asking for anything.
For example, at MCO, Delta, Southwest, Airtran, and most international carriers arrive on Runway 17 because their airsides are on the east side of the field. Most other airlines land on 18R/L as it's closer to their gates. ATC will try their best to get these airplanes on the most convenient runway, and 99% of the time they're successful.
There may be certain times, however, that traffic/weather conditions don't permit such operations, and thus, I've seen parallel approaches to 36R/35 at MCO by BA/Virgin 747's, even though they'll be parking two gates apart.
It is ashamed that FS2002 ATC only seems to recognize one runway, for example, at a time. If I'm departing out of ORD in real life, unless bombs have been dropped on the other 5 runways, 32L/14R is not going to be the *only* active runway. Most likely, in wind conditions favoring 32L departures, ORD will be departing 22L, 32R, 32L from T10 intersection, and landing 27L/R and 22R.
Wish FS could've gotten this right.