I've been flying MS
Flight Simulator since the early 90's, and am just now getting my personal cockpit up to the level of realism that I want. I use Precision Flight Controls hardware - it's without a doubt the very finest available, and the most realistic. Visit them at http://www.flypfc.com/.
This realism does not come cheap. As you'll see in the site, a Jetliner yoke (modeled in the Saab 340 yoke castings) will cost you almost $700, and the rudders are another $500. A good throttle quadrant is around another $500 or so.
My system is rather humble. I'm using the Cirrus yoke and rudder pedals, and for now I use the throttle on the yoke cabinet. I plan to add the throttle quadrant and several sets of throttles for different configurations (737, 747, turboprop, etc) by the end of the year (pending spousal approval, of course!!). I have a great video card that supports dual monitors so I'll likely make the jump to a pair of 19" tubes as well.
It's a great hobby - and there are some amazingly accurate aircraft available for Flight Simulator. My hard drive currently has about 12 gigs (yes, gigabytes) of addons and utilities for my simulator. One aircraft that may show you the realism that MSFS is capable of is the new A-320 from Wilco Publishing. Check this review out - http://www.flightsim.com/cgi/kds?$=main/review/a320pic.htm .
Hope this stokes up some interest in this great hobby!