it's a flight sim, so don't need to take these settings to heart...but this is what I use on the FFX 737-800
Flaps to 5 for take off, reduced thrust to about 90% N1, and rotate somewhere around 155 KIAS to approximately 10degrees.
Positive rate of climb, no runway remaining, gear up.
At 1000' AGL, I begin to retract flaps in increments and engage autopilot.
Initial rate of climb, 3000 fpm (depending on fuel,of course) with an airspeed of 250 KIAS to 10,000'.
From 10,000' to FL180, 280 KIAS, and I try to squeeze out 3000 fpm still.
Once I begin to lose airspeed, I drop down to about 2500 fpm.
FL180 to FL240 @ M.68
FL240 to FL280 @ M.77
FL280 to FL300 and up @ M.80
With these settings and considering fuel load, I can maintain 2500fpm up to around FL260. Then I can maintain about 1500-1800 fpm to cruise at say, FL350.
I get about M.83 or M.84 for cruise at FL350
this is just me, I assume everyone uses something different, so you can experiment.
Maintain own separation with terrain!