You can certainly have the airplane fly from wheels up to wheels (almost) down.
Obviously, the plane will climb to assigned altitudes and follow NAV or GPS
bugs, as well as Frequencies.
When it comes to landing, ILS approaches are great, you can intercept starting at ~20nm out, and once you intercept you simply have flaps, speed and gear to worry about. So easy, obviously.
That being said, I have found you have to take manual controls of the plane at (realistic, real world) minimums. The computer just keeps flying the plane at that descent angle all the way down to the pavement. Good news is, basically, you just pull throttles back to idle, you are already nicely starting to flare if you have managed speed nicely, so a gentle pull back of the stick lowers sink rate and completes a nice flare for a smooth touchdown.
Pretty easy once you get the hang of it, pracitce in missions to get a hang of it. There is a mission where you fly the 747 into Changi (Singapore) (SSS) during a monsoon, you see the runway right at minimums. Once you can manage that, your all ready to go.