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Is the surge of coronavirus cases in the United States a good opportunity to test treatment candidates?

Sun Jul 05, 2020 9:13 pm

Cases in at least 40 of our 50 states are on the uptick at the moment, with Texas, Florida, California, and Arizona leading the way.

Could this be a chance for companies to test the efficacy of potential COVID-19 anti-viral drugs/cures? If a certain drug(s) drastically brings down death and hospitalization rates for COVID-19, then it could really help the country safely reopen certain venues, industries etc during the fall, as effective drugs would be used 1. Drastically reduce the severity of the disease, and 2. Quickly keep infected people out of public circulation.

One example I can think of is Eli-Lilly's potential antibody treatment for COVID-19 that is undergoing research and testing throughout the course of the summer.

Of course, any kind of testing would require the consent of individual patients.
 
PPVRA
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Re: Is the surge of coronavirus cases in the United States a good opportunity to test treatment candidates?

Sun Jul 05, 2020 10:02 pm

All kinds of vaccines, from the Oxford vaccine to a Chinese one, I’m sure others too, and drugs are being tested in Brazil right now. Because we’re still in the thick of it, it makes all the sense.

I’m sure there’s still testing going on in the US.
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Aesma
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Re: Is the surge of coronavirus cases in the United States a good opportunity to test treatment candidates?

Mon Jul 06, 2020 12:19 am

The problem with antiviral drugs is that you must first prove innocuity.

The one that has been tentatively approved, remdesivir, has been in development for many years, so that was already done (well, not all will agree that it's actually innocuous).
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StarAC17
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Re: Is the surge of coronavirus cases in the United States a good opportunity to test treatment candidates?

Mon Jul 06, 2020 4:28 am

Aesma wrote:
The problem with antiviral drugs is that you must first prove innocuity.

The one that has been tentatively approved, remdesivir, has been in development for many years, so that was already done (well, not all will agree that it's actually innocuous).


Also I believe that you have to administer and anti-viral at a certain point when symptoms appear, IIRC if you wait too long then they are useless . They don't really have that kind of timeline available for Covid-19.

Tamiflu for example must be taken withing 48 hours of the onset of symptoms, any longer and its not as effective. Also antivirals aren't supposed to be used if not needed, they are to be used for higher risk people that have a greater chance of complications.
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