CranfordBoy wrote:DNDTUF wrote:I've just booked my second vaccine for the first week of June in France. I got my first dose (Astra Zeneca) when I was back in the UK in March, having been stuck there since Christmas. (I accompanied my mum to the doctor and he asked if I would like to get vaccinated at the same time. Why not ?) On the advice of my GP in France, I've booked an appointment for the Pfizer vaccine for my second dose as AZ is banned in France for under 55s. I was hoping they would introduce a waiver form so that I could get two doses of the same vaccine, but combining both shouldn't be too troublesome. And I didn't want to pay nearly £2000 for hotel quarantine to go back to Scotland for the second dose!!
I'm planning on meeting some friends for a beer tonight, my first time in a bar since the end of October! If it looks too busy or unsafe (given the rather lax approach to lockdown/mask wearing here) I might not bother...
Another poster above has said that Spain is also giving 1st and 2nd doses of different vaccines. Have I missed the news that the EMA has authorised this as safe and effective? Or that the medical regulator anywhere in any country has completed clinical trials that validate such an approach? I know that clinical trials are underway in the UK to establish this (https://www.bbc.co.uk/news/health-56730526) but the only data published to date is a suggestion that vaccine mixing leads to an increased risk of short term side effects and that these may be worse in younger people.
As far as I know there have been no reported cases of clotting after receiving a second dose of AZ. SInce AZ is available in France (and elsewhere in Europe) it seems odd to not give a second dose if the recipient has had no issues with the first, especially if the alternative is an unproven strategy. As I say, apologies if I've missed some news along the way.
From the UK yellow card reporting there are unfortunately a very small numbers of occurance after the second dose. I don't remember exactly were I read it first, but I found a link confirming what I said:
Till 21 April, the regulator had received Yellow Card reports of 209 cases of major thromboembolic events (blood clots) with thrombocytopenia (low platelet counts) in the country on receiving AstraZeneca’s vaccine. Four cases were noted on administering the second dose.
https://www.pharmaceutical-technology.c ... a-vaccine/
There must be newer numbers available.
From the numbers I have seen, the occurance after the 2nd dose is much lower than the already low occurance after the first dose.
While the EMA has confirmed that there is a link between AZ and major thromboembolic events after the 1st dose, I don't know if the numbers of cases after the second dose are high enough to show a link with the vaccine or if the events are in line with the number expected to occur in the general population.
Best regards and stay safe,