Hard to argue with their #1 choice, the ATL-98 Carvair:

It had a capacity of 25 pax and 5 automobiles, yep, someone thought an airborne car ferry was a good idea.
It almost makes an A380 look acceptable in comparison!

And the Boeing X-32 surely deserves to be closer to #1, IMHO.
Ref: http://en.wikipedia.org/wiki/Aviation_Traders_Carvair
[Edited 2016-03-28 11:37:31]