For Boeing it is the customer code that follows. More information here:
http://en.wikipedia.org/wiki/Boeing_customer_code
For Airbus it is based on engine type. Here is a list i put together once:
Model Engine Type
A300B2-1A General Electric CF6-50A
A300B2-1C General Electric CF6-50C
A300B2-203 General Electric CF6-50C2
A300B2K-3C General Electric CF6-50CR
A300B4-103 General Electric CF6-50C2
A300B4-120 Pratt & Whitney JT9D-59A
A300B4-203 General Electric CF6-50C2
A300B4-220 Pratt & Whitney JT9D-59A
A300B4-2C General Electric CF6-50C
A300B4-601 General Electric CF6-80C2A1
A300B4-603 General Electric CF6-80C2A3
A300B4-605R General Electric CF6-80C2A5
A300B4-620 Pratt & Whitney JT9D-7R4H1
A300B4-622 Pratt & Whitney PW4158
A300B4-622R Pratt & Whitney PW4158
A300C4-605R General Electric CF6-80C2A5
A300F4-605R General Electric CF6-80C2A5 or 2A5F
A300F4-622R Pratt & Whitney PW4158
A310-203 General Electric CF6-80A3
A310-20
3C General Electric CF6-80A3
A310-204 General Electric CF6-80C2A2
A310-221 Pratt & Whitney JT9D-7R4D1
A310-222 Pratt & Whitney JT9D-7R4E1
A310-304 General Electric CF6-80C2A2
A310-308 General Electric CF6-80C2A8 or CF6-80C2A2
A310-322 Pratt & Whitney JT9D-7R4E1
A310-324 Pratt & Whitney PW4152
A310-325 Pratt & Whitney PW4156A
A318-111 CFM56-5B8/P
A318-112 CFM56-5B9/P
A318-121 PW6122A
A318-122 PW6124A
A319-111 CFM56-5B5 or 5B5/P
A319-112 CFM56-5B6 or 5B6/P or 5B6/2P
A319-113 CFM56-5A4 or 5A4/F
A319-114 CFM56-5A5 or 5A5/F
A319-115 CFM56-5B7 or 5B7/P
A319-131 IAE Model V2522-A5
A319-132 IAE Model V2524-A5
A319-133 IAE Model V2527M-A5
A320-111 CFM56-5A1 or 5A1/F
A320-211 CFM56-5A1 or 5A1/F
A320-212 CFM56-5A3
A320-214 CFM56-5B4 or 5B4/P or 5B4/2P
A320-216 CFM56-5B6
A320-231 IAE Model V2500-A1
A320-232 IAE Model V2527-A5
A320-233 IAE Model V2527E-A5
A321-111 CFM56-5B1 or 5B1/P or 5B1/2P
A321-112 CFM56-5B2 or 5B2/P
A321-131 IAE Model V2350-A5
A321-211 CFM56-5B3 or 5B3/P or 5B3/2P
A321-212 CFM56-5B1 or 5B1/P or 5B1/2P
A321-213 CFM56-5B2 or 5B2/P
A321-231 IAE Model V2533-A5
A321-232 IAE Model V2530-A5
A330-201
GE CF6-80E1A2
A330-202
GE CF6-80E1A4 / CF6-80E1A4B
A330-203
GE CF6-80E1A3
A330-221 PW4164
A330-222 PW4168
A330-223 PW4168A / PW4168A-1D / PW4168B / PW4170
A330-223F PW4170
A330-243
RR Trent 772B-60
A330-243F
RR Trent 772B-60
A330-244
RR Trent 775-60
A330-301
GE CF6-80E1A2
A330-302
GE CF6-80E1A4 / CF6-80E1A4B
A330-303
GE CF6-80E1A3
A330-321 PW4164
A330-322 PW4168
A330-323 PW4168A / PW4168A-1D / PW4168B / PW4170
A330-341
RR Trent 768-60
A330-342
RR Trent 772-60
A330-343
RR Trent 772B-60
A330-343
RR Trent 772C-60
A340-211 CFM 56-5C2
A340-212 CFM 56-5C3
A340-213 CFM 56-5C4
A340-311 CFM 56-5C2
A340-312 CFM 56-5C3
A340-313 CFM 56-5C4
A340-541
RR Trent 553-61
A340-642
RR Trent 556-61
A380-841
RR Trent 970/B
A380-842
RR Trent 972/B
A380-843F
RR Trent 977/B
A380-861
GP 7270
A380-863F
GP 7277